Clinical evidence summary
Durable CHOLESTEROL COMPLETE®
Durable CHOLESTEROL COMPLETE was formulated by Dr. Kevin Passero using the exact ingredients, dosages, and multi-pathway strategy he has refined with real patients over 20 years of clinical practice.
Every ingredient is backed by peer-reviewed human clinical trials—selected not just for scientific validation, but for results that hold up in the real world.
The Science Behind Every Ingredient
Primary Clinical Study Results
Mollace et al. 2011
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
Placebo-controlled
Double-blind
Randomized controlled trial
−29%
Total cholesterol
−36%
LDL cholesterol
+40%
HDL cholesterol
−39%
Triglycerides
−22%
Blood glucose†
Why it's included: Bergamot works through multiple pathways simultaneously—inhibiting cholesterol production, supporting bile acid excretion, and promoting healthy circulation—which is why it's the only ingredient in this formula shown to move LDL, HDL, and triglycerides all at once.
1,000 mg daily · patented · clinical dose matched
Bergamonte® Citrus Bergamot
1,000
mg daily
Meta-Analysis Results
Trogkanis et al. 2024 (14 RCTS)
A 2024 systematic review pooled results from 14 double-blind randomized controlled trials
spanning 4–24 weeks, with no serious adverse events reported across any of the studies.
A 2024 systematic review pooled results from 14 double-blind randomized controlled trials spanning 4–24 weeks, with no serious adverse events reported across any of the studies.
Placebo-controlled
Double-blind
Meta-analysis
−37.4
mg/dL total cholesterol
Trogkanis et al. 2024
−35.8
mg/dL LDL cholesterol
Trogkanis et al. 2024
14–22%
LDL reduction range
Trogkanis et al. 2024
93.2%
Therapeutic response†
Wang et al. 1997
Why it's included: Red yeast rice is one of the most extensively researched natural ingredients for cholesterol support—with clinical evidence spanning lipid balance, vascular function, inflammatory markers, blood sugar, and blood pressure.* The 1,600mg standardized, organic dose here is 33% higher than most comparable products, formulated to actually deliver results.
Citrinin-free • Extra-strength dose
Organic Red Yeast Rice
1,600
mg daily
Bioavailability Study Results
Petrangolini et al. 2019
In a 14-day crossover trial published in Current Drug Delivery (2019), 12 healthy volunteers each served
as their own control, with plasma CoQ10 levels measured against a standard 100 mg CoQ10 capsule.
A 2024 systematic review pooled results from 14 double-blind randomized controlled trials spanning 4–24 weeks, with no serious adverse events reported across any of the studies.
Active comparator
Crossover protocol
No adverse events
Up to 9×
More absorbable
+41%
Blood CoQ10 rise
48 hrs
Sustained plasma levels
Why it's included: Red yeast rice can deplete CoQ10—the nutrient your heart and muscles rely on for energy—making replenishment essential, not optional. Ubiqsome®'s Phytosome™ delivery system binds CoQ10 to sunflower lecithin for dramatically enhanced solubility, stability, and absorption—delivering 9× more than standard CoQ10 and giving your body access to the benefits most brands can't deliver.
Patented phytosome • Italian-sourced
Ubiqsome® CoQ10 Phytosome
50
mg daily
3 Converging Studies
Susalit et al. 2011 · Hadi et al. 2022 · Lockyer et al. 2015 & 2017
Findings from a double-blind trial of 148 patients confirmed across a 2022 meta-analysis of 819 participants,
with two additional studies supporting reductions in arterial stiffness and inflammation.
Findings from a double-blind trial of 148 patients (Susalit et al., 2011) were confirmed across a 2022 meta-analysis of 819 participants, with two additional studies supporting reductions in arterial stiffness and inflammation.
Double blind
Active-controlled
Meta-analysis
−11.5 mmHg
Systolic BP
−4.8 mmHg
Diastolic BP
↓ Stiffness
Arterial stiffness
↓ IL-8
Inflammation
(p=0.026)
↓ TG
Triglycerides
Why it's included: Cholesterol health is about more than just numbers—it's also about keeping your blood vessels flexible and your circulation healthy. Olive leaf extract supports healthy blood pressure and reduces inflammation that can stress the cardiovascular system.*
Standardized • 20% oleuropein
Olive Leaf Extract
100
mg daily
Inclusion Rationale
Mollace et al. 2011
The original Mollace 2011 bergamot trial included 50 mg of vitamin C (ascorbic acid) in every capsule—
research suggest it helps support the efficacy of the active citrus
compounds.
The original Mollace 2011 bergamot trial included 50 mg of vitamin C (ascorbic acid) in every capsule—research suggests it helps the body more efficiently utilize the active citrus compounds.
Placebo-controlled
Double-blind
Randomized controlled trial
50 mg
Exact trial dose matched
Matched
Replicates landmark study conditions
Why it's included: The original bergamot trial included vitamin C in every capsule—and so does this formula. It's a small but meaningful detail that most other products overlook, included here to match the exact conditions under which bergamot's results were proven.
NON-GMO • BERGAMOT SYNERGIST
Vitamin C (Ascorbic Acid)
50
mg daily
Ready to Try Durable CHOLESTEROL COMPLETE?
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. †Blood glucose reduction applies to metabolic syndrome patients only. †Overall efficacy from Wang 1997 · 446 patients. Results reflect outcomes from peer-reviewed trials at doses consistent with this formula.
The Science Behind Each Ingredient
PATENTED • CLINICAL DOSE
Bergamonte®
Citrus Bergamot
1,000
mg daily
Primary
Clinical Study Results
Mollace et al. 2011
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind, placebo-controlled trial, conducted across two leading Italian research universities.
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
Placebo-controlled
Double-blind
Randomized controlled trial
-29%
total cholesterol
-36%
LDL cholesterol
+40%
HDL cholesterol
−39%
triglycerides
−22%
blood sugar
Why it's included: Bergamot works through multiple pathways simultaneously—inhibiting cholesterol production, supporting bile acid excretion, and promoting healthy circulation—which is why it's the only ingredient in this formula shown to move LDL, HDL, and triglycerides all at once.
Citrinin-free • Extra-strength dose
Organic
Red Yeast Rice
1,600
mg daily
Meta-Analysis Results
Trogkanis et al. 2024
(14 RCTS)
A 2024 systematic review pooled results from 14 double-blind randomized controlled trials spanning 4–24 weeks, with no serious adverse events reported across any of the studies.
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
Placebo-controlled
Double-blind
Meta-analysis
−37.4
mg/dL total cholesterol
Trogkanis et al. 2024
−35.8
mg/dL LDL cholesterol
Trogkanis et al. 2024
14–22%
LDL reduction range
Trogkanis et al. 2024
93.2%
Therapeutic response†
Wang et al. 1997
Why it's included: Red yeast rice is one of the most extensively researched natural ingredients for cholesterol support—with clinical evidence spanning lipid balance, vascular function, inflammatory markers, blood sugar, and blood pressure.* The 1,600mg standardized, organic dose here is 33% higher than most comparable products, formulated to actually deliver results.
Patented• Italian-sourced
Ubiqsome® CoQ10 Phytosome
50
mg daily
Bioavailability
Study Results
Petrangolini et al. 2019
In a 14-day crossover trial published in Current Drug Delivery (2019), 12 healthy volunteers each served as their own control, with plasma CoQ10 levels measured against a standard 100 mg CoQ10 capsule.
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
Active comparator
Crossover protocol
No adverse events
Up to 9×
More absorbable
+41%
Blood CoQ10 rise
48 hrs
Sustained plasma levels
Why it's included: Red yeast rice can deplete CoQ10—the nutrient your heart and muscles rely on for energy—making replenishment essential, not optional. Ubiqsome®'s Phytosome™ delivery system binds CoQ10 to sunflower lecithin for dramatically enhanced solubility, stability, and absorption—delivering 9× more than standard CoQ10 and giving your body access to the benefits most brands can't deliver.
Standardized • 20% oleuropein
Olive Leaf Extract
100
mg daily
3 Converging Studies
Susalit et al. 2011 · Hadi et al. 2022 · Lockyer et al. 2015 & 2017
Findings from a double-blind trial of 148 patients confirmed across a 2022 meta-analysis of 819 participants, with two additional studies supporting reductions in arterial stiffness and inflammation.
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
Double blind
Active-controlled
Meta-analysis
−11.5 mmHg
Systolic BP
−4.8 mmHg
Diastolic BP
↓ Stiffness
Arterial stiffness
↓ IL-8
Inflammation
(p=0.026)
↓ TG
Triglycerides
Why it's included: Cholesterol health is about more than just numbers—it's also about keeping your blood vessels flexible and your circulation healthy. Olive leaf extract supports healthy blood pressure and reduces inflammation that can stress the cardiovascular system.*
NON-GMO • BERGAMOT SYNERGIST
Vitamin C
(Ascorbic Acid)
50
mg daily
Inclusion Rationale
Mollace et al. 2011
The original Mollace 2011 bergamot trial included 50 mg of vitamin C (ascorbic acid) in every capsule— research suggest it helps support the efficacy of the active citrus compounds.
237 adults with elevated cholesterol took part in this 30-day randomized, double-blind,
placebo-controlled trial, conducted across two leading Italian research universities.
Placebo-controlled
Double-blind
Randomized controlled trial
50 mg
Exact trial dose matched
Matched
Replicates landmark study conditions
Why it's included: The original bergamot trial included vitamin C in every capsule—and so does this formula. It's a small but meaningful detail that most other products overlook, included here to match the exact conditions under which bergamot's results were proven.
Ready to Try Durable
CHOLESTEROL COMPLETE?
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. †Blood glucose reduction applies to metabolic syndrome patients only. †Overall efficacy from Wang 1997 · 446 patients. Results reflect outcomes from peer-reviewed trials at doses consistent with this formula.